Despite the heroic efforts and real achievements provided by the Civil Rights movement, the United States remains today a profoundly segregated society. Here we investigate whether racial isolation affects the extent to which prejudice becomes insinuated into the opinions white Americans express on matters of racial policy. Analyzing national survey data well suited to this question, we find that racial isolation generally enhances the impact of prejudice on opinion; that the political potency of prejudice increases insofar as racial isolation prevails in whites' everyday lives. In the conclusion of the article, we locate our results in the broader literature on segregation and draw out their implications for racial politics into the future.